Vitamin C and Skin Health, part II

Collagen is made from cells that originate for mesenchymal stem cells. These are cells found near the blood vessels of various organs throughout the body of adult mammals, including humans!

Cologne.Dog feeds the mesenchymal stem cells of the skin.

The mesenchymal stem cell, also known as a progenitor cell, differentiates in to a collagen producing cell type. The process of cellular differentiation occurs regularly throughout the life of mammals. For instance in the bones there is a continuous breakdown (resorption) and buildup of bone in a manner to regulate calcium levels in the blood, among other factors. In the skin, the differentiation of cells in to a collagen producing type is necessary for the continuous turnover of nails, hair, and the skin itself.

The process of tissue renewal and cellular differentiation is completely normal in the body of adult mammals. In other words, it would be abnormal if the tissues remained static, and did not undergo a process of breaking down and building back up.

As such, there are many types of collagen patterns found in the body. The collagen configuration in the matrix of bones is different from the collagen in the matrix of cartilage. As you can guess, the collagen matrix in the skin is specific for the role collagen plays in the skin, and is different than the collagen configuration of nails and hair that also play special and specific roles in the body.

Cologne.Dog helps the skin make good quality collagen.

No matter where the collagen is located, the formation of collagen occurs either through the process of embryonic development or from a continuous turnover of the tissue, in which case the adult mesenchymal stem cell is the primary source.

Vitamin C plays a very special and critical role in the formation of collagen, no matter where in the body it is being manufactured.

First, a three-dimensional stranded structure is assembled, with the amino acids glycine and proline as its principal components. This is not yet collagen but its precursor, procollagen. Procollagen is then modified, and requires vitamin C as a cofactor.

A long-term deficiency in vitamin C results in impaired collagen synthesis and scurvy. These reactions then result in fibrillary collagen, the most common form of collagen that is then further modified depending on external factors specific to the tissue in which it exists.

In the skin, the extracellular matrix contains specific protein combinations, distributions, and configurations that result in the quality of the skin. What we see as young looking skin or scarred skin all results from the quality of the collagen and the extracellular matrix of the skin.

As you can see, the development of healthy skin is not limited to vitamin C or collagen per se. It is the fundamental balance in the skin proteins that are primarily manufactured from the differentiated product of adult mesenchymal stem cells.

The Cologne.Dog™ Vegan Skin Stem Cell Serum contains a formulation that’s designed to feed the adult mesenchymal stem cells of the skin and to support long term skin health by reinforcing the pathways involved in skin regeneration, maintenance, and healing.

The natural essential oils contained in our formulation also helps with skin health by acting as an antiseptic where the natural processes of the skin can happen without the adverse effects of bacteria, fungi, and parasites that may impede normal and healthy skin maintenance.

You can find more information about our products on our website at, and we’re always available to help and assist with any questions our clients may have about our products or the science behind our formulas.

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