Vitamin C and Skin Health, part I

Vitamin C is a water-soluble vitamin and we do not have large stores of vitamin C in our body. It is constantly used, and depleted, the worst part being that the body does not produce this vital nutrient on its own.

It’s long been known that the lack of ingesting foods that are now associated with containing vitamin C caused a condition named scurvy. People with this disease experience bleeding gums, lost teeth, discolored and scaly skin, and easily get bruised. Other symptoms of scurvy include delayed healing, pain, shortness of breath, and others.

It wasn’t until the two million or so sailors lost their lives during the Age of Discovery that active measures were implemented to prevent its causes. The chief finding was to regularly provide foods containing vitamin C.

The chemical vitamin C is called ascorbic acid, also known as ascorbate, and is found in mirror image forms: l-ascorbate and d-ascorbate.

Effect of Ascorbate on Ectodermal Mesenchymal Stem Cells

Vitamin C stimulates collagen synthesis by increasing the rate of activating genes associated with collagen synthesis. Not only does this chemical have an effect on the differentiation, or specialization, for cells to become collagen manufacturers, it also stimulates them to multiply and increase the number of cells in a regulated fashion.

Without the presence of ascorbate, the undifferentiated stem cells will not go on to become collagen producing cells. Its effects are dose dependent, and the minimum amount of vitamin C to achieve desirable effects is also affected by how it’s absorbed by the body. Topical treatments will generally need higher concentrations of vitamin C to achieve these results on the stem cells of the skin. Another important factor is whether or not other factors exist to assist the vitamin C to penetrate the deeper layers of epidermis, and for the vitamin C to actually reach the stem cells in the first place.

Ascorbate in Photoaging

Photoaging is the natural damage to the skin produced by sunlight, you can read more about it from our previous article titled “PHOTOAGING Uh Oh!”.

Vitamin C plays an important role to reduce the detrimental effects of free radical damage caused by ultraviolet light. Because vitamin C plays such an effective role to reduce the damaging effects of free radicals, we can expect that vitamin C does actually slow down the photoaging process.

Another important note about it is that vitamin C is absorbed and works physiologically to deter the effects of photoaging. This is in contrast to the mechanism of sunscreen, for example, where it works from the outside to block damage caused by ultraviolet light. Vitamin C literally works from the inside out to benefit skin and body health.

Anti-Aging Properties of Ascorbate

Vitamin C is absolutely critical for the formation of collagen. Not only does it play a major role in getting cells to produce collagen in the first place, it also plays a biophysical role to incorporate the amino acid proline into collagen, which is a vital and essential part of the collagen synthesis process. These processes are highly interwoven to the formation of elastin, another important protein that delivers anti-aging benefits for beauty.

One can expect the skin to become more wrinkled and aged with a deficiency of collagen producing cells, and a deficiency in the presence of collagen in the skin matrix. It’s very important to note that the processes of creating and losing collagen in the skin are continuously ongoing. The skin is constantly making new matrix, and vitamin C is necessary all the time! In the presence of vitamin C, the skin is able to manufacture collagen, which in turn reduces wrinkles, and achieves desirable anti-aging effects.

It’s been noted that vitamin C plays such a critical role in the skin that high doses of it have been associated to a reduction in scarring, and a noticeable increase in the ability of the body to heal from skin injuries. This should make sense since vitamin C plays such an important role systemically to get cells to create collagen, and for the collagen that they make to be effective with the incorporation of key amino acids that vitamin C is required to incorporate.

Other Effects

You may know the adage that “vitamin C is good for the immune system”. People often take vitamin C at high doses at the beginning of a cold or sniffles to prevent a more serious cold. It turns out several cells of the immune system indeed accumulate vitamin C, and they use the vitamin C for the ability to perform their immune tasks. This is especially true for the cells who go in to damaged areas to clean out debris and to eliminate foreign agents, such as bacteria. Clinically, vitamin C deficiency is observed to correlate to a reduced resistance against pathogens, while a higher supply of vitamin C is associated with enhanced immune system functionality.

The link to the immune system actually spreads so far wide that it’s still very poorly understood. Autoimmune conditions, including normal processes that have autoimmune like properties such as menopause, are all affected adversely by the absence of vitamin C, and affected positively by the presence of vitamin C. This can be visually seen by the effects of skin pigmentation.

Melanocytes are generally known to play some role during immune response, while the absence of vitamin C is associated with abnormal pigmentation. The presence of vitamin C plays an important role in the normal pigmentation of the skin. Its role is attributed to the creation of melanin as an oxidative side product, and a powerful antioxidant like vitamin C counteracts the oxidative stress that’s associated with melanin. There are other mechanisms, so many others, and many ways we haven’t even begun to yet solve — vitamin C is an absolute gem of a molecule, and it is indeed so critical for skin health.

The Cologne.Dog™ Solution

Studies exist that observed the solubility and structure of vitamin C in solvents, such as alcohol, are markedly and adversely affected. Vitamin C is a sensitive chemical that oxidizes rapidly, and chemical solvents are known for their oxidative abilities. The absence of solvents, therefore, is not only ideal, it is critical for proper vitamin C delivery.

The Cologne.Dog™ Vegan Skin Stem Cell Serum™ contains a supersaturated concentration of vitamin C to benefit the skin health of our clients. The solvent-free solution of our products makes it ideal for delivering this nutrient for the desired benefits we mentioned above. Every bottle of our products is designed to deliver key nutrients, including vitamin C, to the actual cells responsible for making the collagen. It’s not only our passion, it’s exactly our specialty.

To find out more, please visit